Browsing Experimentally Confirmed database

Result: Your query found 15 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
cmeD
  • BacMet ID: BAC0615
  • Code for: Efflux
  • Family: RND superfamily, OMF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: CmeD is the outer membrane protein.
  • Length (amino acid): 424
  • Reference: Akiba et al. 2006, Pubmed- 16303882

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeE
  • BacMet ID: BAC0616
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: CmeE is a periplasmic fusion protein
  • Length (amino acid): 246
  • Reference: Akiba et al. 2006, Pubmed- 16303882

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeF
  • BacMet ID: BAC0069
  • Code for: Efflux
  • Family: RND superfamily; AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: Integral membrane component of efflux system (Multidrug efflux system CmeDEF)
  • Length (amino acid): 1005
  • Reference: Akiba et al. 2006, Pubmed- 16303882

    		• Similar resistance genes in 'BacMet Predicted database'
    farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrA
  • BacMet ID: BAC0256
  • Code for: Regulator
  • Family: AraC/XylS family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol]
  • Description: Two component sensory transduction transcriptional regulatory protein MtrA; play an important role in enhancing transcription of the mtrCDE operon
  • Length (amino acid): 301
  • Reference: Rouquette et al. 1999; Pubmed- 10417654

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrC
  • BacMet ID: BAC0257
  • Code for: Efflux
  • Family: MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane]
  • Description: Membrane fusion protein MtrC; part of MtrCDE efflux pump; Cell membrane lipoprotein, involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents
  • Length (amino acid): 412
  • Reference: Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176, Veal et al. 1998; Pubmed- 9534233

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrD
  • BacMet ID: BAC0258
  • Code for: Efflux
  • Family: AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol]
  • Description: Antibiotic resistance efflux pump component mtrD; part of MtrCDE efflux pump
  • Length (amino acid): 1067
  • Reference: Veal et al. 1998; Pubmed- 9534233, Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrE
  • BacMet ID: BAC0259
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain NCCP11945)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid]
  • Description: Antibiotic resistance efflux pump component ; Outer membrane protein mtrE; part of MtrCDE efflux pump
  • Length (amino acid): 467
  • Reference: Delahay et al. 1997; Pubmed- 9245802, Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrF
  • BacMet ID: BAC0260
  • Code for: Efflux
  • Family: ABG ransporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain NCCP11945)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol]
  • Description: Antibiotic resistance efflux pump component mtrF; inner membrane protein
  • Length (amino acid): 533
  • Reference: Veal et al. 2003; Pubmed- 12493784, Folster et al. 2006; Pubmed- 15901695

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrR
  • BacMet ID: BAC0261
  • Code for: Regulator
  • Family: TetR (tetracycline resistance) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane]
  • Description: HTH-type transcriptional regulator MtrR; Repressor of the mtrC gene. the major repressor of mtrCDE expression; Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents
  • Length (amino acid): 210
  • Reference: Pan et al. 1994; Pubmed- 8196548, Hagman et al. 1995; Pubmed- 7711899

    		• Similar resistance genes in 'BacMet Predicted database'
    vexA
  • BacMet ID: BAC0527
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol]
  • Description: The function of vexAB efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. Works as VexAB-TolC efflux system.
  • Length (amino acid): 368
  • Reference: Bina et al. 2006; Pubmed- 16804679

    		• Similar resistance genes in 'BacMet Predicted database'
    vexB
  • BacMet ID: BAC0424
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol]
  • Description: Multidrug efflux transporter VexB. The function of vexAB efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. A double mutant of vexAB and vexCD showed a marked increase in deoxycholate susceptibility, whereas no significant change in deoxycholate susceptibility was observed in vexAB or vexCD single-deletion mutants.
  • Length (amino acid): 1036
  • Reference: Bina et al. 2006; Pubmed- 16804679, Bina et al. 2008; Pubmed- 18490456, Rahman et al. 2007; Pubmed- 18037783

    		• Similar resistance genes in 'BacMet Predicted database'
    vexH
  • BacMet ID: BAC0509
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: VexH contributes to antimicrobial resistance and exhibits broad substrate specificity. VexH is important for intestinal colonization and virulence factor production. V. cholerae RND efflux pumps (e.g. vexAB, vexCD etc.) have redundant functions, not only in antimicrobial resistance, but also in virulence factor production. RND efflux system contribute to V. cholerae pathogenesis in two ways. First, the RND efflux systems function to provide the bacterium with protection against antimicrobial compounds that are present in the host. Second, the RND efflux systems are required for efficient production of virulence factors. VexH can confer resistance to antibitics such as ampicillin and novobiocin.
  • Length (amino acid): 1036
  • Reference: Taylor et al. 2012; Pubmed- 22666485

    		• Similar resistance genes in 'BacMet Predicted database'
    vexK
  • BacMet ID: BAC0428
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol]
  • Description: Multidrug efflux transporter vexK
  • Length (amino acid): 1037
  • Reference: Bina et al. 2008; Pubmed- 18490456

    		• Similar resistance genes in 'BacMet Predicted database'
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